Fénichel P, Sosset C
Service d'Endocrinologie et Reproduction (Pr M. Harter), Hôpital de l'Archet, Nice.
Contracept Fertil Sex. 1997 Jul-Aug;25(7-8):639-42.
In case of spontaneous, idiopathic, karyotypically normal premature ovarian failure (POF), autoimmune disease's characteristics have to be verified: association with other autoimune diseases, initial psychological stress, circulating antibodies to thyroid, adrenal or the ovaries, particular HLA haplotypes. Ovarian follicular activity can be measured by ultrasonography. Estrogentherapy is able to enhance ovarian activity. The potential benefit of corticosteroid therapy needs further evaluation.
对于自发性、特发性、染色体核型正常的卵巢早衰（POF），必须核实自身免疫性疾病的特征：与其他自身免疫性疾病的关联、初始心理压力、针对甲状腺、肾上腺或卵巢的循环抗体、特定的人类白细胞抗原（HLA）单倍型。卵巢卵泡活性可通过超声检查来测量。雌激素疗法能够增强卵巢活性。皮质类固醇疗法的潜在益处需要进一步评估。
