伴有和不伴有内分泌性眼病的甲状腺毒症患者中的人类白细胞抗原Cw3

HLA CW3 in thyrotoxicosis patients with and without endocrine ophthalmopathy.

作者信息

Mayr W R, Ludwig H, Schernthaner G, Höfer R

出版信息

Tissue Antigens. 1976 Apr;7(4):243-6. doi: 10.1111/j.1399-0039.1976.tb01062.x.

DOI:10.1111/j.1399-0039.1976.tb01062.x

Abstract

Fifty-four thyrotoxic patients (23 with and 31 without endocrine ophthalmopathy EOP) were HLA typed for A, B, and C locus antigens. The frequency of this third locus antigen CW3 was found to be significantly increased in patients with EOP compared with those thyrotoxic patients without EOP. These findings point to a possible genetic heterogeneity in thyrotoxic patients with or without EOP. HLA B8 was observed in only 10 of the 54 patients studied, which is not in accordance with the previously reported statistically significant increased frequency of this B locus antigen in thyrotoxic patients.

摘要

对54例甲状腺毒症患者（23例伴有内分泌性眼病[EOP]，31例不伴有EOP）进行了A、B和C位点抗原的HLA分型。结果发现，与不伴有EOP的甲状腺毒症患者相比，伴有EOP的患者中该第三位点抗原CW3的频率显著增加。这些发现表明，伴有或不伴有EOP的甲状腺毒症患者可能存在基因异质性。在所研究的54例患者中，仅10例观察到HLA B8，这与先前报道的甲状腺毒症患者中该B位点抗原频率统计学显著增加不一致。