Cakmak M, Nayci A, Renda N, Erekul S, Gökçora H, Yücesan S
Department of Pediatric Surgery, Ankara University Medical Faculty, Turkey.
Int Surg. 1997 Oct-Dec;82(4):371-5.
Caustic Esophageal Burns (CEB) usually results in scatritial tissue and stricture formation. Management requires preventing the massive inflammatory process that ensues in its early phase and decreasing bacterial complications.
An animal model was created to investigate the effect of corticosteroids and pentoxifylline in CEB using 52 male Wistar rats. The injury was produced using an indwelling esophageal catheter through which 3N of 12% sodium hydroxide was infused. The rats were grouped as control, CEB, CEB and ceftazidime (CEB-C, 100 mg/kg/day im. bid. 10 days), CEB and ceftazidime plus dexamethasone (CEB-CD, 0.1 mg/kg/day im. bid. 4 weeks) and CEB and ceftazidime plus pentoxifylline (CEB-CP, 50 mg/kg/day im. tid. 4 weeks). The groups were evaluated making use of esophagograms, hydroxyproline (OH-P) contents and histologic examination of the specimens 28 days after injury.
No significant statistical differences were observed among the dexamethasone (CEB-CD), pentoxifylline (CEB-CP), antibiotics (CEB-C) and the untreated CEB groups.
腐蚀性食管烧伤（CEB）通常会导致瘢痕组织和狭窄形成。治疗需要预防早期随之而来的大规模炎症过程并减少细菌并发症。
使用52只雄性Wistar大鼠建立动物模型，以研究皮质类固醇和己酮可可碱对CEB的影响。通过留置食管导管注入3N的12%氢氧化钠造成损伤。大鼠分为对照组、CEB组、CEB加头孢他啶组（CEB-C，100mg/kg/天，肌肉注射，每日两次，共10天）、CEB加头孢他啶加地塞米松组（CEB-CD，0.1mg/kg/天，肌肉注射，每日两次，共4周）和CEB加头孢他啶加己酮可可碱组（CEB-CP，50mg/kg/天，肌肉注射，每日三次，共4周）。在损伤28天后，利用食管造影、羟脯氨酸（OH-P）含量和标本的组织学检查对各组进行评估。
地塞米松（CEB-CD）、己酮可可碱（CEB-CP）、抗生素（CEB-C）组与未治疗的CEB组之间未观察到显著的统计学差异。
