Kaye P L
Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia.
Rev Reprod. 1997 May;2(2):121-7. doi: 10.1530/ror.0.0020121.
The robust independence of preimplantation embryo development in vitro suggests that the developmental programme is autonomous. The rapid accumulation of evidence during the last decade for participation of many hormones, growth factors and their receptors in these early stages of embryogenesis has challenged this conclusion. In this review, the insulin and epidermal growth factor families, which have been best studied in mice, are used to illustrate the different roles growth factors may play in preimplantation physiology and the circuits that possibly mediate their participation. Tumour necrosis factor alpha, an inhibitory factor and growth hormone previously considered to be restricted to orchestrating postnatal growth and development, is also discussed. In the absence of results indicating the existence of a master regulatory factor, the data support the hypothesis that the redundancy of growth factor actions may provide fail-safe protection to the preimplantation developmental programme.
体外植入前胚胎发育强大的独立性表明，发育程序是自主的。在过去十年中，大量证据表明许多激素、生长因子及其受体参与了胚胎发生的这些早期阶段，这对这一结论提出了挑战。在本综述中，以在小鼠中研究得最为充分的胰岛素和表皮生长因子家族为例，来说明生长因子在植入前生理学中可能发挥的不同作用以及可能介导其参与的途径。还讨论了肿瘤坏死因子α，一种以前被认为仅参与协调出生后生长和发育的抑制因子和生长激素。在缺乏表明存在主调控因子的结果的情况下，数据支持以下假设：生长因子作用的冗余性可能为植入前发育程序提供故障安全保护。
