白细胞介素-6的表达及其对胃癌细胞系细胞生长的影响。
Expression of interleukin-6 and its effect on the cell growth of gastric carcinoma cell lines.
作者信息
Ito R, Yasui W, Kuniyasu H, Yokozaki H, Tahara E
机构信息
First Department of Pathology, Hiroshima University School of Medicine.
出版信息
Jpn J Cancer Res. 1997 Oct;88(10):953-8. doi: 10.1111/j.1349-7006.1997.tb00314.x.
Abstract
The expression and the effect of IL-6 were examined in human gastric carcinoma cell lines to determine whether IL-6 serves as a growth stimulator. The expression of IL-6 mRNA was detected in three (TMK-1, MKN-1, MKN-7) of 8 gastric carcinoma cell lines. All three cell lines secreted IL-6 into the culture fluid, in large amounts in the cases of MKN-1 and MKN-7 cells. Scatchard plot analysis of IL-6 binding revealed that MKN-1 and MKN-7 cells had both high- and low-affinity receptors. Cell growth of MKN-1 and MKN-7 cells was stimulated by IL-6, while anti-IL-6 antibody inhibited growth. The expression of IL-1 alpha mRNA by these three cell lines was induced by IL-6. IL-1 alpha increased the expression of mRNA for IL-6 by TMK-1 cells. These findings indicate that IL-6 induced by IL-1 alpha is an autocrine growth factor for some gastric carcinomas.
摘要
在人胃癌细胞系中检测白细胞介素-6（IL-6）的表达及作用，以确定IL-6是否作为生长刺激因子。在8种胃癌细胞系中的3种（TMK-1、MKN-1、MKN-7）检测到IL-6 mRNA的表达。所有这三种细胞系均将IL-6分泌到培养液中，在MKN-1和MKN-7细胞中分泌量很大。对IL-6结合的Scatchard图分析显示，MKN-1和MKN-7细胞具有高亲和力和低亲和力受体。IL-6刺激MKN-1和MKN-7细胞的生长，而抗IL-6抗体抑制生长。这三种细胞系的IL-1α mRNA表达由IL-6诱导。IL-1α增加了TMK-1细胞IL-6 mRNA的表达。这些发现表明，由IL-1α诱导的IL-6是某些胃癌的自分泌生长因子。
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