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幽门螺杆菌感染中的局部免疫反应

Local Immune Response in Helicobacter pylori Infection.

作者信息

Kivrak Salim Derya, Sahin Mehmet, Köksoy Sadi, Adanir Haydar, Süleymanlar Inci

机构信息

From the Department of Medical Oncology (DKS), Faculty of Medicine, Akdeniz University, Antalya; Faculty of Health Sciences (MS), Kahramanmaras Sutcu Imam University, Kahramanmaras; Department of Microbiology (SK); and Department of Gastroenterology (HA, IS), Faculty of Medicine, Akdeniz University, Antalya, Turkey.

出版信息

Medicine (Baltimore). 2016 May;95(20):e3713. doi: 10.1097/MD.0000000000003713.

DOI:10.1097/MD.0000000000003713
PMID:27196487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4902429/
Abstract

There have been few studies concerning the cytokine profiles in gastric mucosa of Helicobacter pylori-infected patients with normal mucosa, chronic gastritis, and gastric carcinoma (GAC).In the present study, we aimed to elucidate the genomic expression levels and immune pathological roles of cytokines-interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-4, IL-6, IL-10, transforming growth factor (TGF)-β, IL-17A, IL-32-in H pylori-infected patients with normal gastric mucosa (NGM; control), chronic active gastritis (CAG), and GAC. Genomic expression levels of these cytokines were assayed by real-time PCR analysis in gastric biopsy specimens obtained from 93 patients.We found that the genomic expression levels of IFN-γ, TNF-α, IL-6, IL-10, IL-17A mRNA were increased in the CAG group and those of TNF-α, IL-6, IL-10, IL-17A, TGF-β mRNA were increased in the GAC group with reference to H pylori-infected NGM group.This study is on the interest of cytokine profiles in gastric mucosa among individuals with normal, gastritis, or GAC. Our findings suggest that the immune response of gastric mucosa to infection of H pylori differs from patient to patient. For individual therapy, levels of genomic expression of IL-6 or other cytokines may be tracked in patients.

摘要

关于幽门螺杆菌感染的正常黏膜、慢性胃炎和胃癌（GAC）患者胃黏膜中的细胞因子谱，相关研究较少。在本研究中，我们旨在阐明细胞因子——干扰素（IFN）-γ、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-4、IL-6、IL-10、转化生长因子（TGF）-β、IL-17A、IL-32——在幽门螺杆菌感染的正常胃黏膜（NGM；对照组）、慢性活动性胃炎（CAG）和GAC患者中的基因表达水平及免疫病理作用。通过实时PCR分析对从93例患者获取的胃活检标本中这些细胞因子的基因表达水平进行了检测。我们发现，与幽门螺杆菌感染的NGM组相比，CAG组中IFN-γ、TNF-α、IL-6、IL-10、IL-17A mRNA的基因表达水平升高，GAC组中TNF-α、IL-6、IL-10、IL-17A、TGF-β mRNA的基因表达水平升高。本研究关注正常、胃炎或GAC个体胃黏膜中的细胞因子谱。我们的研究结果表明，胃黏膜对幽门螺杆菌感染的免疫反应因患者而异。对于个体化治疗，可在患者中追踪IL-6或其他细胞因子的基因表达水平。

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