Martins C, Fonseca I, Roque L, Soares J
Departamento de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa, Portugal.
Oral Oncol. 1997 Sep;33(5):344-7. doi: 10.1016/s1368-8375(97)00011-0.
Warthin's tumour is a peculiar subtype of monomorphic adenomas of the salivary glands, frequently cystic, and that characteristically associates an epithelial glandular cell component to a dense lymphoid infiltrate. Short-term cultures from 12 Warthin's tumours of salivary glands, including 5 previously reported cases were successfully karyotyped and clonal numerical and/or structural changes were detected in 7 of them (58%). 3 cases showed numerical abnormalities with loss of chromosomes Y (2 cases) and X (1 case). The remaining 4 abnormal cases presented the following structural changes: complex translocation t(11;19;16)(q21;p12;p13.3); reciprocal translocations t(6;8)(p23;q22) and t(6;15)(p21;q15) (2 cases); and 1p22, 3p26, 11p13 changes. In 1 case, clonal numerical deviations (+ 7 and -Y) were concurrent with the structural rearrangement t(6;8). Two of these aberrations are suggested to be Warthin's tumour-associated: 11q;19p translocation has already been described in 3 cases, and structural rearrangements of 6p23 have also been reported in another case. Our study extends the cytogenetic information about Warthin's tumour and identifies two recurrent abnormalities --6p rearrangements and t(11;19)--specific for this salivary neoplasm.
沃辛瘤是唾液腺单形性腺瘤的一种特殊亚型，常为囊性，其特征是上皮腺细胞成分与密集的淋巴细胞浸润相关。对12例唾液腺沃辛瘤进行短期培养（包括5例先前报道的病例），成功进行了核型分析，其中7例（58%）检测到克隆性数目和/或结构改变。3例显示数目异常，分别缺失Y染色体（2例）和X染色体（1例）。其余4例异常病例呈现以下结构改变：复杂易位t(11;19;16)(q21;p12;p13.3)；相互易位t(6;8)(p23;q22)和t(6;15)(p21;q15)（2例）；以及1p22、3p26、11p13改变。1例中，克隆性数目偏差（+7和-Y）与结构重排t(6;8)同时存在。其中两种畸变被认为与沃辛瘤相关：11q;19p易位已在3例中描述过，6p23的结构重排也在另一例中报道过。我们的研究扩展了关于沃辛瘤的细胞遗传学信息，并确定了两种该唾液腺肿瘤特有的复发性异常——6p重排和t(11;19)。
