Bartek J, Bartkova J, Lukas J
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark.
Exp Cell Res. 1997 Nov 25;237(1):1-6. doi: 10.1006/excr.1997.3776.
Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.
生物医学研究各个领域的最新发现相互融合，揭示了细胞周期调控的分子基础，以及颠覆这种稳态机制在癌症发展中的关键作用。这些过程的核心是由“RB途径”控制的G1晚期检查点，本综述简要评估了其分子组成、功能以及与癌症相关的缺陷。这一令人兴奋的新知识在细胞生物学中引发了大量概念性问题，对生物技术和医学具有潜在的实际意义。
