Steiner T S, Lima A A, Nataro J P, Guerrant R L
Division of Geographic and International Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
J Infect Dis. 1998 Jan;177(1):88-96. doi: 10.1086/513809.
Enteroaggregative E. coli (EAggEC) are emerging as an important cause of persistent diarrhea, especially in children in the developing world, yet the pathogenesis of EAggEC infection is poorly understood. In an ongoing prospective study of childhood diarrhea in an urban Brazilian slum, EAggEC are the leading cause of persistent diarrhea. Children from this study with EAggEC and persistent diarrhea had significant elevations in fecal lactoferrin, interleukin (IL)-8, and IL-1beta. Moreover, children with EAggEC without diarrhea had elevated fecal lactoferrin and IL-1beta concentrations. The children with EAggEC in their stool had significant growth impairment after their positive culture, regardless of the presence or absence of diarrhea. Finally, 2 EAggEC strains were shown to cause IL-8 release from Caco-2 cells, apparently via a novel heat-stable, high-molecular-weight protein. These findings suggest that EAggEC may contribute to childhood malnutrition, trigger intestinal inflammation in vivo, and induce IL-8 secretion in vitro.
肠集聚性大肠杆菌（EAggEC）正逐渐成为持续性腹泻的一个重要病因，尤其是在发展中国家的儿童中，然而人们对EAggEC感染的发病机制了解甚少。在巴西一个城市贫民窟正在进行的一项关于儿童腹泻的前瞻性研究中，EAggEC是持续性腹泻的主要病因。该研究中患有EAggEC和持续性腹泻的儿童粪便乳铁蛋白、白细胞介素（IL）-8和IL-1β显著升高。此外，没有腹泻的EAggEC患儿粪便乳铁蛋白和IL-1β浓度升高。粪便中检测出EAggEC的儿童在培养结果呈阳性后，无论有无腹泻，均出现明显的生长发育迟缓。最后，有2株EAggEC菌株被证明可通过一种新型热稳定高分子量蛋白，诱导Caco-2细胞释放IL-8。这些发现表明，EAggEC可能导致儿童营养不良，在体内引发肠道炎症，并在体外诱导IL-8分泌。
