Bertrand P, Delhommais A, Alison D, Rouleau P
Département de Radiologie Adultes, CHU Tours, France.
Acad Radiol. 1995 Aug;2(8):683-6. doi: 10.1016/s1076-6332(05)80436-2.
We compared the tolerance and efficacy of iohexol-300, a nonionic low-osmolar monomer, with those of ioxaglate-320, an ionic low-osmolar dimer, in lower limb phlebography.
One hundred twenty inpatients were randomly divided into two groups in this double-blind comparative study. Two hundred milliliters of contrast medium (100 ml per leg) was injected intravenously. The immediate tolerance was classified as discomfort (i.e., sensation of warmth, pain, coldness related to the injection) and adverse events occurring up to 1 hr after administration. Delayed tolerance was followed up to 8 days after the examination. The main parameter was immediate adverse events. Image quality was assessed by a radiologist using a visual analog scale.
The number of immediate adverse events was significantly higher in the ioxaglate group (p < .02). The more frequent events were digestive disorders and skin rashes; 13 of these events were reported in the ioxaglate group, but none were reported in the iohexol group (p < .001). The other parameters were not significantly different in the two groups.
We found a similar efficacy and a better tolerance of iohexol-300 than ioxaglate-320 in lower limb phlebography.
我们比较了非离子型低渗单体碘海醇-300与离子型低渗二聚体碘克沙醇-320在下肢静脉造影中的耐受性和有效性。
在这项双盲对比研究中，120名住院患者被随机分为两组。静脉注射200毫升造影剂（每条腿100毫升）。即刻耐受性分为不适（即与注射相关的温热感、疼痛、寒冷感）以及给药后1小时内发生的不良事件。延迟耐受性在检查后随访8天。主要参数为即刻不良事件。由放射科医生使用视觉模拟量表评估图像质量。
碘克沙醇组即刻不良事件的数量显著更高（p < 0.02）。较常见的事件为消化系统紊乱和皮疹；碘克沙醇组报告了13起此类事件，而碘海醇组未报告任何此类事件（p < 0.001）。两组的其他参数无显著差异。
我们发现在下肢静脉造影中，碘海醇-300与碘克沙醇-320疗效相似，但前者耐受性更佳。
