Kopf A W, Bart R S, Gladstein A H
Arch Dermatol. 1976 Jun;112(6):801-7.
Sixteen patients were treated for melanotic freckle of Hutchinson (lentigo maligna) with the Miescher technique of x-ray therapy. Eleven patients had no local cutaneous recurrences of persistence following x-ray therapy. Five patients had local recurrence or persistence of their lesions. Three patients developed metastatic malignant melanoma. The first of these three patients had lentigo maligna melanoma, and the second patient had a melanotic freckle with atypical cells extending down the adnexae, including the sweat apparatus to the level of the coiled portion of one sweat gland. The third patient was considered to be in a precancerous phase at the time of irradiation. Nevertheless, metastases occurred. European colleagues indicate that they have not experienced such problems in using the Miescher technique. The procedure has been abandoned in our department, pending further clarification of the discrepancy between our results and those reported by our European colleagues.
16例哈钦森黑素雀斑（恶性雀斑样痣）患者接受了米舍尔X线治疗技术。11例患者在接受X线治疗后无局部皮肤复发或持续存在。5例患者出现局部复发或病变持续存在。3例患者发生转移性恶性黑色素瘤。这3例患者中的第一例患有恶性雀斑样痣黑色素瘤，第二例患者有黑素雀斑，非典型细胞延伸至附属器，包括汗腺至一个汗腺盘曲部水平。第三例患者在照射时被认为处于癌前期。然而，仍发生了转移。欧洲的同事表示，他们在使用米舍尔技术时未遇到此类问题。在我们进一步澄清我们的结果与欧洲同事报告的结果之间的差异之前，我们科室已放弃了该程序。
