Rabinowitz M, Wetherill G, Kopple J
Arch Environ Health. 1976 Jul-Aug;31(4):220-3. doi: 10.1080/00039896.1976.10667223.
Three adult men were fed 204 Pb - a rare, stable isotope of lead - daily for about 100 days. Simultaneous blood and facial hair measurements of this tracer and of total lead concentrations were made by mass spectrometric isotope dilution analysis. Although the blood showed an immediate response to the intake of the tracer, the facial hair showed a more gradual response and a delay of approximately 35 days. Since the pattern of appearance of lead in hair does not appear to represent a simple time delay of blood lead concentration, the existence of a physiological pool of lead fed by the blood and giving rise to the content in hair is suggested. Hair lead values should, therefore, be interpreted as the integral of the blood lead values over the mean life of this intermediate pool - about 100 days.
三名成年男性连续约100天每日摄入204Pb（一种罕见的稳定铅同位素）。通过质谱同位素稀释分析法同时对这种示踪剂和总铅浓度进行血液和面部毛发测量。尽管血液对示踪剂的摄入表现出即时反应，但面部毛发的反应更为缓慢，延迟约35天。由于毛发中铅的出现模式似乎并非血铅浓度的简单时间延迟，因此提示存在一个由血液供给铅的生理池，它导致了毛发中的铅含量。因此，毛发铅值应被解释为该中间池平均寿命（约100天）内血铅值的积分。
