Preuss H G
Dept of Medicine (Nephrology Division), Georgetown University Medical Center, Washington DC 20007, USA.
Geriatr Nephrol Urol. 1997;7(2):81-6. doi: 10.1023/a:1008249001782.
The present investigation examined effects of diets containing different proportions of macronutrients on longevity in two substrains of normotensive Wistar rats--Wistar Kyoto (WKY), the most widely accepted normotensive control for spontaneously hypertensive rats (SHR) and Munich Wistar rats (WAM as designated here). Each substrain was divided into five dietary groups composed of 15 rats each. Compared to a baseline diet composed of near equal calories of sucrose, fat, and protein, the remaining four diets were high sucrose-low protein, high sucrose-low fat, low sucrose-high protein, and low sucrose-high fat. Significantly higher systolic blood pressures were found in the two groups of WKY and WAM ingesting the high sucrose diets compared to the other three groups. The high sucrose groups were also hyperinsulinemic. Although only the group of WKY consuming the high sucrose-low fat diet showed a significantly shortened lifespan, the lifespan of WKY positively correlated with systolic blood pressure when data from all dietary groups were combined. WKY and WAM with an average systolic blood pressure exceeding 150 mm Hg had a significantly shorter lifespan than the rats with lower average blood pressure. Accordingly, elevated systolic blood pressure, especially when the blood pressure exceeds 150 mm Hg, significantly shortens lifespan.
本研究考察了含有不同比例常量营养素的饮食对正常血压的Wistar大鼠的两个亚系——Wistar Kyoto（WKY）和慕尼黑Wistar大鼠（在此称为WAM）寿命的影响。WKY是自发性高血压大鼠（SHR）最广泛接受的正常血压对照品系。每个亚系分为五个饮食组，每组15只大鼠。与由蔗糖、脂肪和蛋白质热量近乎相等组成的基线饮食相比，其余四种饮食分别为高蔗糖 - 低蛋白、高蔗糖 - 低脂、低蔗糖 - 高蛋白和低蔗糖 - 高脂肪。与其他三组相比，摄入高蔗糖饮食的两组WKY和WAM的收缩压显著更高。高蔗糖组也存在高胰岛素血症。尽管只有摄入高蔗糖 - 低脂饮食的WKY组显示寿命显著缩短，但当合并所有饮食组的数据时，WKY的寿命与收缩压呈正相关。平均收缩压超过150 mmHg的WKY和WAM的寿命明显短于平均血压较低的大鼠。因此，收缩压升高，尤其是当血压超过150 mmHg时，会显著缩短寿命。
