多次注射盐酸米诺环素治疗症状性孤立性肝囊肿的长期疗效

Long-term results of multiple minocycline hydrochloride injections for the treatment of symptomatic solitary hepatic cyst.

作者信息

Yoshida Hiroshi, Onda Masahiko, Tajiri Takashi, Arima Yasuo, Mamada Yasuhiro, Taniai Nobuhiko, Akimaru Koho

机构信息

First Department of Surgery, Nippon Medical School, Tokyo, Japan.

出版信息

J Gastroenterol Hepatol. 2003 May;18(5):595-8. doi: 10.1046/j.1440-1746.2003.03025.x.

DOI:10.1046/j.1440-1746.2003.03025.x

PMID:12702053

Abstract

BACKGROUND

The current study presents the long-term results of multiple minocycline hydrochloride (MINO) injections for the treatment of symptomatic solitary hepatic cyst.

METHODS

From 1989 to 1998, nine patients were referred for the treatment of a symptomatic solitary hepatic cyst, comprising two males and seven females aged between 41-72 years (mean 58.2 years). The chief complaint in all cases was upper abdominal discomfort or pain. Mean cyst diameter was 14.1 +/- 2.3 cm. After insertion of an 8 or 9-French catheter into the cyst, 200 mg of MINO in 10 mL saline was injected and the catheter was flushed with 10 mL saline, for a total of 20 mL saline. The catheter was then clamped for 30 min. MINO injection was performed daily for 7-8 days, after which time the catheter was removed.

RESULTS

One patient complained of moderate right subscapular pain immediately after the injection, and one patient complained of pain at the site of catheter insertion. Patients were followed for 42-153 months (mean 85 months). Cyst regression without recurrence was documented in all patients.

CONCLUSIONS

Multiple injections of MINO are safe, definitive treatments for symptomatic solitary hepatic cyst.

摘要

背景

本研究展示了多次注射盐酸米诺环素（MINO）治疗有症状的孤立性肝囊肿的长期结果。

方法

1989年至1998年，9例有症状的孤立性肝囊肿患者前来接受治疗，包括2例男性和7例女性，年龄在41至72岁之间（平均58.2岁）。所有病例的主要症状为上腹部不适或疼痛。囊肿平均直径为14.1±2.3厘米。将一根8或9法式导管插入囊肿后，在10毫升盐水中注入200毫克MINO，并用10毫升盐水冲洗导管，总共使用20毫升盐水。然后将导管夹闭30分钟。每天注射MINO，持续7至8天，之后拔除导管。