巴豆和麻疯树种子蛋白质的研究。毒性特性及体外对蛋白质合成的抑制作用。
Studies on the proteins from the seeds of Croton tiglium and of Jatropha curcas. Toxic properties and inhibition of protein synthesis in vitro.
作者信息
Stirpe F, Pession-Brizzi A, Lorenzoni E, Strocchi P, Montanaro L, Sperti S
出版信息
Biochem J. 1976 Apr 15;156(1):1-6. doi: 10.1042/bj1560001.
Abstract
- Proteins extracted from the seeds of the Euphorbiaceae croton tiglium and Jatropha curcas were separated into three major peaks (I,II,and III) by Sephadex chromatography. 2. The crude protein from both seeds and peaks I and II from Croton and peak I from Jatropha were toxic to mice, to different extents. 3. The crude protein and peak I and peak II from both seeds, inhibited protein synthesis by a reticulocyte lysate; maximum inhibition was exerted by peak II from both seeds. None of these preparations affected protein synthesis in vitro by Ehrlich ascites cells.
摘要
- 从大戟科巴豆和麻疯树种子中提取的蛋白质，经葡聚糖凝胶柱色谱法分离为三个主要峰（I、II和III）。2. 两种种子的粗蛋白以及巴豆的峰I和峰II、麻疯树的峰I对小鼠均有不同程度的毒性。3. 两种种子的粗蛋白、峰I和峰II均能抑制网织红细胞裂解物的蛋白质合成；两种种子的峰II抑制作用最强。这些制剂均不影响艾氏腹水癌细胞的体外蛋白质合成。
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