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哺乳动物体内蛋白质合成的调节。给予亚致死剂量放线菌酮后大鼠肝脏和肾脏中的蛋白质合成。

Regulation of mammalian protein synthesis in vivo. Protein synthesis in rat liver and kidney after the administration of sublethal doses of cyclohyximide.

作者信息

Rothblum L I, Devlin T M, Ch'ih J J

出版信息

Biochem J. 1976 Apr 15;156(1):151-7. doi: 10.1042/bj1560151.

DOI:10.1042/bj1560151
PMID:942397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163726/
Abstract

Protein synthesis in vivo was studied at various times after the administration of sublethal doses of cycloheximide to rats. Cycloheximide caused an inhibition, followed by a dose-and time-dependent stimulation, of incorportation of labelled precursor into proteins of the liver and kidney. The stimulation of protein synthesis at 24h was not due to a change of precursor pool or the specific radioactivity of the precursor used. During the stimulatory period, leucine incorporation into various cellular protein fractions varied; incorporation into total nuclear protein was the most affected.

摘要

在给大鼠注射亚致死剂量的环己酰亚胺后的不同时间，研究了体内蛋白质合成情况。环己酰亚胺导致肝脏和肾脏蛋白质中标记前体掺入受到抑制，随后出现剂量和时间依赖性刺激。24小时时蛋白质合成的刺激并非由于前体库的变化或所用前体的比放射性改变。在刺激期，亮氨酸掺入各种细胞蛋白质组分的情况各不相同；掺入总核蛋白的情况受影响最大。

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Regulation of mammalian protein synthesis in vivo. Protein synthesis in rat liver and kidney after the administration of sublethal doses of cyclohyximide.哺乳动物体内蛋白质合成的调节。给予亚致死剂量放线菌酮后大鼠肝脏和肾脏中的蛋白质合成。
Biochem J. 1976 Apr 15;156(1):151-7. doi: 10.1042/bj1560151.
2
Regulation of mammalian protein synthesis in vivo. Stimulated protein synthesis in liver in vivo after cycloheximide treatment.哺乳动物体内蛋白质合成的调控。环己酰亚胺处理后体内肝脏中蛋白质合成的刺激情况。
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.环己酰亚胺：哺乳动物细胞中蛋白质合成抑制的相关方面
Science. 1964 Dec 11;146(3650):1474-6. doi: 10.1126/science.146.3650.1474.
3
INHIBITION OF THE SYNTHESIS OF PROTEIN IN INTACT ANIMALS BY ACETOXYCYCLOHEXIMIDE AND A METABOLIC DERANGEMENT CONCOMITANT WITH THIS BLOCKADE.乙酰氧基环己酰亚胺对完整动物体内蛋白质合成的抑制作用以及伴随这种阻断的代谢紊乱。
Biochem Pharmacol. 1963 Aug;12:855-65. doi: 10.1016/0006-2952(63)90116-3.
4
Evans blue space in tissues of the rat.大鼠组织中的伊文思蓝空间
Am J Physiol. 1955 Nov;183(2):317-21. doi: 10.1152/ajplegacy.1955.183.2.317.
5
Studies on the free amino acids and related compounds in the tissues of the cat.猫组织中游离氨基酸及相关化合物的研究。
J Biol Chem. 1954 Dec;211(2):927-39.
6
The free amino acids of human blood plasma.人血浆中的游离氨基酸。
J Biol Chem. 1954 Dec;211(2):915-26.
7
Nuclei from rat liver: isolation method that combines purity with high yield.大鼠肝脏细胞核：一种将纯度与高产率相结合的分离方法。
Science. 1966 Dec 30;154(3757):1662-5. doi: 10.1126/science.154.3757.1662.
8
Effects of cycloheximide on DNA and protein synthesis in rat liver.放线菌酮对大鼠肝脏DNA和蛋白质合成的影响。
Proc Soc Exp Biol Med. 1969 Jun;131(2):601-5. doi: 10.3181/00379727-131-33935.
9
The biochemical pathology of inhibition of protein synthesis in vivo. The effects of cycloheximide on hepatic parenchymal cell ultrastructure.体内蛋白质合成抑制的生化病理学。放线菌酮对肝实质细胞超微结构的影响。
Lab Invest. 1969 Jun;20(6):529-36.
10
Further studies with glutarimide antibiotics. II. Some effects of cycloheximide pretreatment on hepatic protein synthesis and release of nascent polypeptides in intact and adrenalectomized rats.戊二酰亚胺类抗生素的进一步研究。II. 环己酰亚胺预处理对完整和肾上腺切除大鼠肝脏蛋白质合成及新生多肽释放的一些影响。
Biochem Pharmacol. 1968 May;17(5):839-42. doi: 10.1016/0006-2952(68)90026-9.