哺乳动物体内蛋白质合成的调节。给予亚致死剂量放线菌酮后大鼠肝脏和肾脏中的蛋白质合成。
Regulation of mammalian protein synthesis in vivo. Protein synthesis in rat liver and kidney after the administration of sublethal doses of cyclohyximide.
作者信息
Rothblum L I, Devlin T M, Ch'ih J J
出版信息
Biochem J. 1976 Apr 15;156(1):151-7. doi: 10.1042/bj1560151.
Abstract
Protein synthesis in vivo was studied at various times after the administration of sublethal doses of cycloheximide to rats. Cycloheximide caused an inhibition, followed by a dose-and time-dependent stimulation, of incorportation of labelled precursor into proteins of the liver and kidney. The stimulation of protein synthesis at 24h was not due to a change of precursor pool or the specific radioactivity of the precursor used. During the stimulatory period, leucine incorporation into various cellular protein fractions varied; incorporation into total nuclear protein was the most affected.
摘要
在给大鼠注射亚致死剂量的环己酰亚胺后的不同时间，研究了体内蛋白质合成情况。环己酰亚胺导致肝脏和肾脏蛋白质中标记前体掺入受到抑制，随后出现剂量和时间依赖性刺激。24小时时蛋白质合成的刺激并非由于前体库的变化或所用前体的比放射性改变。在刺激期，亮氨酸掺入各种细胞蛋白质组分的情况各不相同；掺入总核蛋白的情况受影响最大。
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