放线菌酮对人肺肿瘤、再生大鼠肝脏及肝癌中蛋白质合成的影响。
Effects of cycloheximide on protein synthesis in human lung tumors, regenerating rat liver and hepatomas.
作者信息
Agostini C, Muci F
出版信息
Experientia. 1979 Apr 15;35(4):518-9. doi: 10.1007/BF01922743.
PMID:571350
Abstract
10(-4) M cycloheximide (CHM) inhibits leucine incorporation to about the same degree in slices of human lung tumors, rat hepatomas, regenerating livers and normal tissues. At 10(-6) M, CHM has a more pronounced effect on tumor tissue and regenerating liver than on normal tissues. 10(-8) M CHM stimulates protein synthesis in normal rat liver slices.
摘要
10⁻⁴M放线菌酮（CHM）对人肺肿瘤切片、大鼠肝癌切片、再生肝切片和正常组织切片中亮氨酸掺入的抑制程度大致相同。在10⁻⁶M时，CHM对肿瘤组织和再生肝的作用比对正常组织的作用更为明显。10⁻⁸M CHM可刺激正常大鼠肝切片中的蛋白质合成。
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