α-氰基肉桂酸酯衍生物抑制线粒体丙酮酸转运体的机制。
The mechanism of the inhibition of the mitochondrial pyruvate transportater by alpha-cyanocinnamate derivatives.
作者信息
Halestrap A P
出版信息
Biochem J. 1976 Apr 15;156(1):181-3. doi: 10.1042/bj1560181.
Abstract
Pyruvate transport into rat liver mitochondria is inhibited by a variety of thiol reagents. alpha-Cyanocinnamate and its derivates, potent and reversible inhibitors of pyruvate transport, react reversibly with mercaptoethanol and cysteine to form addition products. It is concluded that these inhibitors react with an essential thiol group on the pyruvate carrier.
摘要
丙酮酸转运至大鼠肝脏线粒体的过程受到多种硫醇试剂的抑制。α-氰基肉桂酸及其衍生物是丙酮酸转运的强效可逆抑制剂，它们可与巯基乙醇和半胱氨酸发生可逆反应，形成加成产物。由此得出结论，这些抑制剂与丙酮酸载体上的一个必需硫醇基团发生反应。
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本文引用的文献
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The transport of pyruvate in rat liver mitochondria.丙酮酸在大鼠肝脏线粒体中的转运
FEBS Lett. 1971 Jan 30;12(5):285-288. doi: 10.1016/0014-5793(71)80200-4.
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Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate.α-氰基-4-羟基肉桂酸对大鼠肝脏线粒体和人红细胞中丙酮酸转运的特异性抑制作用。
Biochem J. 1974 Feb;138(2):313-6. doi: 10.1042/bj1380313.
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On the mechanism of translocation of pyruvate and other monocarboxylic acids in rat-liver mitochondria.大鼠肝脏线粒体中丙酮酸及其他一元羧酸转运机制的研究
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The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compounds.α-氰基-4-羟基肉桂酸及相关化合物对分离的线粒体和完整组织制剂中丙酮酸转运的抑制作用的特异性及其代谢意义。
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The transport of monocarboxylic oxoacids in rat liver mitochondria.大鼠肝线粒体中单羧酸氧代酸的转运
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