肌醇代谢作用的研究。放射性肌醇在雄性大鼠体内的分布。
Studies on the metabolic role of myo-inositol. Distribution of radioactive myo-inositol in the male rat.
作者信息
Lewin L M, Yannai Y, Sulimovici S, Kraicer P F
出版信息
Biochem J. 1976 May 15;156(2):375-80. doi: 10.1042/bj1560375.
Abstract
Radioactive myo-inositol was injected intraperitoneally into nephrectomized rats. The radioactive material present in liver, spleen, brain, heart, diaphragm, seminal vesicle, coagulating gland, prostate, epididymis, vas deferens and testis was shown to consist exclusively of myo-inositol and its derivatives, as shown by paper chromatography of hydrolysates and trichloroacetic acid extracts of these tissues. Radioactive myo-inositol was accumulated rapidly within 1 h by the thyroid, coagulating gland and seminal vesicle. Other tissues, such as the pituitary, prostate gland, liver and spleen, concentrated myo-inositol less actively. The muscle tissues studied (diaphragm and heart) concentrated little inositol, whereas brain, testis, and epididymal fat-pad did not concentrate it at all. The lipid fraction of liver contained most of the radio-labelled myo-inositol. In the other organs most of the radioactivity was found in the aqueous trichloroacetic acid extract, largely as free myo-inositol.
摘要
将放射性肌醇经腹腔注射到肾切除的大鼠体内。通过对这些组织的水解产物和三氯乙酸提取物进行纸色谱分析表明，肝脏、脾脏、大脑、心脏、横膈膜、精囊、凝固腺、前列腺、附睾、输精管和睾丸中存在的放射性物质仅由肌醇及其衍生物组成。放射性肌醇在1小时内迅速被甲状腺、凝固腺和精囊积累。其他组织，如垂体、前列腺、肝脏和脾脏，对肌醇的浓缩活性较低。所研究的肌肉组织（横膈膜和心脏）对肌醇的浓缩很少，而大脑、睾丸和附睾脂肪垫则根本不浓缩。肝脏的脂质部分含有大部分放射性标记的肌醇。在其他器官中，大部分放射性存在于三氯乙酸水提取物中，主要以游离肌醇的形式存在。
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