Isturiz M A, De Bracco M M, Pizzi A M, Manni J A
Arthritis Rheum. 1976 Jul-Aug;19(4):725-30. doi: 10.1002/1529-0131(197607/08)19:4<725::aid-art1780190411>3.0.co;2-y.
Reduced antibody-dependent cell-mediated cytotoxicity (ADCC) was demonstrated in lymphocytes of patients with rheumatoid arthritis (RA). Rheumatoid factor (RF) positive sera inhibited ADCC of normal lymphocytes by reacting both with effector and target cells (sensitized chicken red blood cells). These sera were fractionated by specific adsorption or gradient ultracentrifugation, and isolated RF or RF negative fractions were tested for their ability to inhibit ADCC by reacting with normal human lymphocytes or target cells. RF was ineffective on normal lymphocytes but it strongly inhibited the reaction by interaction with target cells. IgG RF negative fractions of certain sera were inhibitory by direct interaction with effector cells.
类风湿关节炎（RA）患者淋巴细胞中抗体依赖性细胞介导的细胞毒性（ADCC）降低。类风湿因子（RF）阳性血清通过与效应细胞和靶细胞（致敏鸡红细胞）反应，抑制正常淋巴细胞的ADCC。这些血清通过特异性吸附或梯度超速离心进行分级分离，分离出的RF或RF阴性组分通过与正常人淋巴细胞或靶细胞反应来测试其抑制ADCC的能力。RF对正常淋巴细胞无效，但通过与靶细胞相互作用强烈抑制反应。某些血清的IgG RF阴性组分通过与效应细胞直接相互作用具有抑制作用。
