DNA修复：聚（ADP - 核糖）聚合酶——另一位守护天使？
DNA repair: PARP - another guardian angel?
作者信息
Jeggo P A
机构信息
MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK.
出版信息
Curr Biol. 1998 Jan 15;8(2):R49-51. doi: 10.1016/s0960-9822(98)70032-6.
PMID:9427640
Abstract
Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.
摘要
聚（ADP-核糖）聚合酶（PARP）存在缺陷的细胞系和小鼠具有升高的自发基因重排以及对应激的异常反应。这些结果可能由对自由基诱导损伤的反应改变来解释，并表明PARP限制了此类损伤导致的基因组不稳定性。
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