Stetson M H, Watson-Whitmyre M
Science. 1976 Jan 16;191(4223):197-9. doi: 10.1126/science.942799.
Destruction of the suprachiasmatic nuclei in the golden hamster by bilateral radiofrequency lesions abolishes three well-documented circadian rhythms--locomotor activity, estrous cyclicity, and photoperiodic photosensitivity. Entrainment of these rhythms by light cycles fails in lesioned hamsters; females become persistently estrous; in both sexes locomotor activity becomes sporadic, confined primarily to the light instead of darkness, and is totally arrhythmic when lesioned animals are exposed to continuous darkness; the photoperiodic gonadal response (gonadal regression induced by short day lengths) is abolished; lesioned animals remain reproductively mature irrespective of photoperiodic treatment.
通过双侧射频损伤破坏金黄地鼠的视交叉上核，会消除三个有充分记录的昼夜节律——运动活动、发情周期和光周期光敏感性。光照周期对这些节律的调节在损伤的仓鼠中失效；雌性会持续发情；在两性中，运动活动变得零星，主要局限于光照而非黑暗时段，并且当损伤的动物暴露于持续黑暗中时完全无节律；光周期性腺反应（短日照诱导的性腺退化）被消除；无论光周期处理如何，损伤的动物仍保持生殖成熟。
