Ulubelen A, Topcu G, Johansson C B
Faculty of Pharmacy, University of Istanbul, Turkey.
J Nat Prod. 1997 Dec;60(12):1275-80. doi: 10.1021/np9700681.
From the roots of Salvia multicaulis, four new aromatic norditerpenoids, multicaulin (1), 12-demethylmulticauline (2), multiorthoquinone (3), and 12-demetylmultiorthoquinone (4), two new abietane diterpenoids, 12-methyl-5-dethydrohorminone (5) and 12-methyl-5-dehydroacetylhorminone (6), as well as a new pimarane diterpenoid, salvipimarone (7), were isolated. Also obtained in this investigation were the known compounds alpha-amyrin, hinokione, horminone, lupeol, manool, 1-oxoferruginol, 18-oxoferruginol, pisiferal, and sempervirol. The structures of compounds 1-7 were established by 1D and 2D NMR techniques and by chemical methods. The antituberculous activity of 1-7 was tested against Mycobacterium tuberculosis strain H37Rv, and all compounds were found to be significantly active, with 2 and 4-6 being the most potent substances. Six of these novel compounds were evaluated against a number of additional bacterial cultures.
从多茎鼠尾草的根部分离出了四种新的芳香型降二萜类化合物，即多茎素（1）、12-去甲基多茎素（2）、多邻苯二醌（3）和12-去甲基多邻苯二醌（4），两种新的枞酸型二萜类化合物，12-甲基-5-脱氢霍米酮（5）和12-甲基-5-脱氢乙酰霍米酮（6），以及一种新的海松烷型二萜类化合物，鼠尾草海松酮（7）。在本次研究中还得到了已知化合物α-香树脂醇、日桧酮、霍米酮、羽扇豆醇、马尼醇、1-氧代铁锈醇、18-氧代铁锈醇、豌豆素和长生草醇。化合物1-7的结构通过一维和二维核磁共振技术以及化学方法得以确定。对化合物1-7针对结核分枝杆菌H37Rv菌株的抗结核活性进行了测试，发现所有化合物均具有显著活性，其中2以及4-6是活性最强的物质。对其中六种新型化合物针对多种其他细菌培养物进行了评估。
