来自唇形罗勒和非洲鼠尾草的生物活性二萜类化合物。

Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea.

作者信息

Hussein Ahmed A, Meyer Jacobus J M, Jimeno María L, Rodríguez Benjamín

机构信息

Department of Chemistry of Medicinal Plants, National Research Center, El-Tahrir Street, Dokki, Cairo, Egypt.

出版信息

J Nat Prod. 2007 Feb;70(2):293-5. doi: 10.1021/np0680376. Epub 2007 Jan 27.

DOI:10.1021/np0680376

PMID:17256988

Abstract

The known (+)-trans-ozic acid (1) and two new labdane diterpenoids (2 and 3) have been isolated from an ethanol extract of Orthosiphon labiatus. The structures of 2 and 3 were established mainly by 1D and 2D NMR spectroscopic means. The ethanolic extract of Salvia africana-lutea afforded the known abietane diterpenoids carnosol (4), rosmadial (5), and carnosic acid (characterized as its derivative 6). Compounds 3 and 6 exhibited MICs of 157 and 28 microM, respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 microM, respectively, against a breast (MCF-7) human cancer cell line.

摘要

已从猫须草的乙醇提取物中分离出已知的（+）-反式蛇麻脂酸（1）和两种新的半日花烷二萜（2和3）。2和3的结构主要通过一维和二维核磁共振光谱手段确定。南非丹参的乙醇提取物得到了已知的松香烷二萜鼠尾草酚（4）、迷迭香二醛（5）和鼠尾草酸（以其衍生物6表征）。化合物3和6对结核分枝杆菌的最低抑菌浓度分别为157和28微摩尔，而2和6对人乳腺癌（MCF-7）细胞系分别表现出细胞毒性活性，半数抑制浓度分别为82和69微摩尔。