Sucak G T, Ogur G, Topal G, Ataoglu O, Cankus G, Haznedar R
Department of Hematology, Gazi University Medical School, Ankara, Turkey.
Cancer Genet Cytogenet. 1998 Jan 15;100(2):152-4. doi: 10.1016/s0165-4608(97)00026-5.
Clonal chromosomal aberrations are reported in about 25% of the patients with hairy cell leukemia (HCL). No consistent cytogenetic abnormality has been described in HCL; most of the chromosomal changes found have been deletions and inversions, with the rare occurrence of translocations. While most of the chromosomal aberrations in HCL are common to the ones found in B cell chronic lymphocytic leukemia and other B cell lymphoproliferative disorders, there are also certain chromosomal changes that are not found in other B cell lymphoproliferative disorders. We present here a 63-year-old male patient with hairy cell leukemia with the clonal del(17)(q25), which has not previously been reported in HCL.
约25%的毛细胞白血病（HCL）患者存在克隆性染色体异常。HCL中尚未描述出一致的细胞遗传学异常；所发现的大多数染色体变化为缺失和倒位，易位情况罕见。虽然HCL中的大多数染色体异常与B细胞慢性淋巴细胞白血病及其他B细胞淋巴增殖性疾病中发现的异常相同，但也存在某些在其他B细胞淋巴增殖性疾病中未发现的染色体变化。我们在此报告一名63岁的毛细胞白血病男性患者，其存在克隆性del(17)(q25)，这在HCL中此前尚未有报道。
