Lledo P M, Zhang X, Südhof T C, Malenka R C, Nicoll R A
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
Science. 1998 Jan 16;279(5349):399-403. doi: 10.1126/science.279.5349.399.
The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP. Introducing SNAP, a protein that promotes membrane fusion, into cells enhanced synaptic transmission, and this enhancement was significantly less when generated in synapses that expressed LTP. Thus, postsynaptic fusion events, which could be involved either in retrograde signaling or in regulating postsynaptic receptor function or both, contribute to LTP.
我们研究了突触后细胞中的膜融合事件对于长期增强作用（LTP）所导致的突触强度变化是否必要。向突触后细胞中引入能在多个不同步骤阻断膜融合的物质会降低LTP。向细胞中引入促进膜融合的蛋白质SNAP会增强突触传递，而在表达LTP的突触中产生这种增强作用时，其程度会显著降低。因此，可能参与逆行信号传导或调节突触后受体功能或两者兼具的突触后融合事件，对LTP有贡献。
