Yataco A, Talo H, Rowe P, Kass D A, Berger R D, Calkins H
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Clin Auton Res. 1997 Dec;7(6):293-7. doi: 10.1007/BF02267720.
Recent studies have reported a close association between chronic fatigue syndrome and neurally mediated hypotension. We hypothesized that this association may result from an abnormality in autonomic function among patients with chronic fatigue syndrome, which may be detectable using an analysis of heart rate variability. We prospectively studied 19 patients who fulfilled the Centers for Disease Control criteria for chronic fatigue syndrome and 11 controls. Each subject underwent a two-stage tilt-table test while wearing a Holter monitor. Heart rate variability was assessed in the supine baseline position and during upright tilt using frequency domain parameters. In the baseline supine position, high frequency (HF) power, low frequency (LF) power, and the ratio of low frequency power to high frequency power (LF/HF ratio) were similar. In both patient groups, upright tilt resulted in a similar decrease in HF power, increase in LF power, and increase in the LH/HF ratio. In conclusion, autonomic function, as assessed using an analysis of heart rate variability, does not differ in the baseline supine state, nor in response to upright tilt among patients with chronic fatigue syndrome and healthy controls.
近期研究报告称慢性疲劳综合征与神经介导性低血压之间存在密切关联。我们推测这种关联可能源于慢性疲劳综合征患者自主神经功能异常，这或许可通过心率变异性分析检测出来。我们前瞻性地研究了19名符合美国疾病控制中心慢性疲劳综合征标准的患者以及11名对照者。每位受试者在佩戴动态心电图监测仪时接受两阶段倾斜试验。使用频域参数在仰卧位基线状态和直立倾斜过程中评估心率变异性。在仰卧位基线状态下，高频（HF）功率、低频（LF）功率以及低频功率与高频功率之比（LF/HF比值）相似。在两组患者中，直立倾斜均导致HF功率类似程度降低、LF功率增加以及LH/HF比值增加。总之，通过心率变异性分析评估的自主神经功能，在慢性疲劳综合征患者和健康对照者的仰卧位基线状态下并无差异，对直立倾斜的反应也无差异。
