Hoxie N J, Davis J P, Vergeront J M, Nashold R D, Blair K A
Bureau of Public Health, Madison, WI, USA.
Am J Public Health. 1997 Dec;87(12):2032-5. doi: 10.2105/ajph.87.12.2032.
This study estimated the magnitude of cryptosporidiosis-associated mortality in the Milwaukee vicinity for 2 years following a massive waterborne outbreak.
Death certificates were reviewed.
During approximately 2 years before the outbreak, cryptosporidiosis was listed as an underlying or contributing cause of death on the death certificates of four Milwaukee-vicinity residents. In the approximately 2 years after the outbreak, this number was 54, of whom 85% had acquired immunodeficiency syndrome (AIDS) listed as the underlying cause of death. In the first 6 months after the outbreak, the number of death certificates indicating AIDS, but not cryptosporidiosis, as a cause of death was 19 (95% confidence interval = 12.26) higher than preoutbreak trends would have predicted.
Waterborne outbreaks of cryptosporidium infection can result in significant mortality, particularly among immunocompromised populations. Any discussion of policies to ensure safe drinking water must consider the potential fatal consequences of waterborne cryptosporidiosis among immunocompromised populations.
本研究估计了在一次大规模水源性隐孢子虫病暴发后的两年里，密尔沃基附近地区隐孢子虫病相关的死亡率。
对死亡证明进行了审查。
在暴发前约两年时间里，密尔沃基附近地区有4名居民的死亡证明上，隐孢子虫病被列为根本死因或死因之一。在暴发后的约两年里，这一数字为54例，其中85%的人潜在死因被列为获得性免疫缺陷综合征（艾滋病）。在暴发后的头6个月里，将艾滋病而非隐孢子虫病列为死因的死亡证明数量比暴发前趋势预测的高出19例（95%置信区间=12.26）。
水源性隐孢子虫感染暴发可导致显著的死亡率，尤其是在免疫功能低下人群中。任何关于确保安全饮用水政策的讨论都必须考虑水源性隐孢子虫病在免疫功能低下人群中可能产生的致命后果。
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