细胞周期蛋白盒折叠：细胞周期与转录调控中的蛋白质识别
The cyclin box fold: protein recognition in cell-cycle and transcription control.
作者信息
Noble M E, Endicott J A, Brown N R, Johnson L N
机构信息
Oxford Centre for Molecular Sciences, UK.
出版信息
Trends Biochem Sci. 1997 Dec;22(12):482-7. doi: 10.1016/s0968-0004(97)01144-4.
Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.
细胞周期和基因转录的调控对于细胞生长和分裂的有序进行至关重要。最近关于两种细胞周期蛋白（细胞周期蛋白A和细胞周期蛋白H）以及两种转录因子中介蛋白（TFIIB和视网膜母细胞瘤肿瘤抑制蛋白（Rb）的A口袋区域）结构的研究结果表明，尽管它们的序列相似度很低，但它们共享具有惊人相似α螺旋拓扑结构的结构域。
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