Nelson E B, Sax K W, Strakowski S M
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA.
Am J Psychiatry. 1998 Jan;155(1):137-9. doi: 10.1176/ajp.155.1.137.
The authors examined Continuous Performance Test scores of patients with major depression with or without psychosis and schizophrenia.
Patients with major depression with psychosis (N = 13), major depression without psychosis (N = 14), and schizophrenia (N = 15) and normal volunteers (N = 14) completed the degraded-stimulus version of the Continuous Performance Test. Patients were rated with the Hamilton Depression Rating Scale and measures of positive formal thought disorder.
Continuous Performance Test scores of patients with major depression with psychosis and schizophrenia were significantly worse than those of patients with major depression without psychosis and of normal volunteers. Positive formal thought disorder was correlated with performance on this test in patients with schizophrenia.
These findings suggest that attentional impairment on the Continuous Performance Test is associated with psychosis in general and may be specifically associated with positive formal thought disorder in patients with schizophrenia.
作者研究了伴有或不伴有精神病性症状的重度抑郁症患者以及精神分裂症患者的持续性操作测验分数。
伴有精神病性症状的重度抑郁症患者（N = 13）、不伴有精神病性症状的重度抑郁症患者（N = 14）、精神分裂症患者（N = 15）以及正常志愿者（N = 14）完成了持续性操作测验的退化刺激版本。使用汉密尔顿抑郁量表对患者进行评分，并测量阳性形式思维障碍。
伴有精神病性症状的重度抑郁症患者和精神分裂症患者的持续性操作测验分数显著低于不伴有精神病性症状的重度抑郁症患者和正常志愿者。在精神分裂症患者中，阳性形式思维障碍与该测验的表现相关。
这些发现表明，持续性操作测验中的注意力损害一般与精神病性症状有关，并且可能在精神分裂症患者中与阳性形式思维障碍有特定关联。
