Lalani I, Bhol K, Ahmed A R
Department of Oral Medicine, Harvard School of Dental Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Ann Allergy Asthma Immunol. 1997 Dec;79(6):469-83. doi: 10.1016/S1081-1206(10)63052-9.
Reading this article will increase the readers' knowledge of the biology of interleukin-10 (IL-10) an important cytokine. The survival of an organism and its host defense mechanisms require, among other processes, a complex but target-oriented interaction and an interdependence between the immune and inflammatory pathways. The biologic role of interleukin-10 in these processes is presented as well as the possible involvement of IL-10 in the pathogenesis of various diseases. The influence of pharmacologic agents on IL-10 production and the possible pharmacologic role of IL-10 itself are discussed.
A detailed literature search was conducted. Studies considered relevant and important involving both humans and animals, in all languages were used.
Material was taken only from peer reviewed journals.
IL-10 is produced by CD4+, Tho, Th1, B lymphocytes, mast cells, eosinophils, monocytes, macrophages and keratinocytes. IL-10 has a diverse array of actions, which differ depending on cell type, nature of stimulus and the cellular microenvironment. Interleukin-10 has an important role in the inflammatory and immune systems. In addition, present studies suggest that IL-10 may well play a pivotal role in the pathogenesis of several diseases. It has the potential for therapeutic use. Most of the data on IL-10 have been obtained from in vitro studies or animal experiments. Studies on humans are few, but rapidly increasing.
Interleukin-10 is an important molecule with a central role in maintaining health and in the pathogenesis of disease. Known pharmacologic agents and some under investigation can modify IL-10 production in vivo. Development of agents that can selectively affect a very specific biologic action of IL-10 may provide significant benefit in treating autoimmune and inflammatory diseases.
阅读本文将增加读者对白细胞介素 -10（IL-10）这一重要细胞因子生物学特性的了解。生物体的存活及其宿主防御机制除其他过程外，还需要免疫和炎症途径之间复杂但目标明确的相互作用和相互依存关系。本文介绍了白细胞介素 -10在这些过程中的生物学作用，以及IL-10在各种疾病发病机制中的可能参与情况。还讨论了药物制剂对IL-10产生的影响以及IL-10本身可能的药理作用。
进行了详细的文献检索。使用了所有语言的、涉及人类和动物的被认为相关且重要的研究。
材料仅取自同行评审期刊。
IL-10由CD4 +、Th0、Th1、B淋巴细胞、肥大细胞、嗜酸性粒细胞、单核细胞、巨噬细胞和角质形成细胞产生。IL-10具有多种作用，其作用因细胞类型、刺激性质和细胞微环境而异。白细胞介素 -10在炎症和免疫系统中起重要作用。此外，目前的研究表明IL-10很可能在几种疾病的发病机制中起关键作用。它具有治疗用途的潜力。关于IL-10的大多数数据来自体外研究或动物实验。对人类的研究较少，但正在迅速增加。
白细胞介素 -10是一种重要分子，在维持健康和疾病发病机制中起核心作用。已知的药物制剂和一些正在研究的制剂可以在体内改变IL-10的产生。开发能够选择性影响IL-10非常特定生物学作用的药物可能在治疗自身免疫性和炎性疾病方面带来显著益处。
