同胞对法与方差成分法在基因组筛查中的比较。
Comparison of sib-pair and variance-components methods for genomic screening.
作者信息
Pugh E W, Jaquish C E, Sorant A J, Doetsch J P, Bailey-Wilson J E, Wilson A F
机构信息
National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.
出版信息
Genet Epidemiol. 1997;14(6):867-72. doi: 10.1002/(SICI)1098-2272(1997)14:6<867::AID-GEPI51>3.0.CO;2-K.
The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.
使用问题2中的核心家系数据比较了同胞对和方差成分连锁分析方法的统计特性。总体而言，两种方法检测连锁的效能都不高。方差成分法在检测连锁方面具有更好的效能，特别是当模型中纳入协变量时。两种方法的I型错误率均与名义错误率相似。
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