Segal E, Sandovsky-Losica H
Sabouraudia. 1981 Dec;19(4):267-73.
A study was carried out to determine whether protection against experimental systemic candidiasis can be induced by vaccination with Candida albicans ribosomes in animals compromised by cyclophosphamide (CY) treatment. ICR mice treated with CY showed a reduction in the number of leukocytes and a decrease in spleen and body weights. CY-treated mice were more susceptible to intraperitoneal (IP) or intravenous (IV) challenge with live C. albicans than the untreated animals. Vaccination of CY-treated mice with C. albicans ribosomes, with or without addition of incomplete Freund's adjuvant, led to a partial protection against a lethal IP or IV challenge with live yeasts. These results indicate the possible effectiveness of ribosomal vaccination in protecting the compromised host against experimental candidiasis.
开展了一项研究，以确定在受到环磷酰胺（CY）治疗而免疫功能受损的动物中，用白色念珠菌核糖体进行疫苗接种是否能诱导对实验性系统性念珠菌病的保护作用。经CY处理的ICR小鼠白细胞数量减少，脾脏和体重下降。与未处理的动物相比，经CY处理的小鼠对活的白色念珠菌腹腔内（IP）或静脉内（IV）攻击更敏感。用白色念珠菌核糖体对经CY处理的小鼠进行疫苗接种，无论是否添加不完全弗氏佐剂，均可对活酵母的致死性IP或IV攻击产生部分保护作用。这些结果表明核糖体疫苗接种在保护免疫功能受损宿主免受实验性念珠菌病侵害方面可能具有有效性。
