Geyer M, Wittinghofer A
Max-Planck-Institut für medizinische Forschung, Abteilung Biophysik, Heidelberg, Germany.
Curr Opin Struct Biol. 1997 Dec;7(6):786-92. doi: 10.1016/s0959-440x(97)80147-9.
Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated.
细胞生物学依赖于大分子之间的相互作用，如蛋白质 - DNA、蛋白质 - 蛋白质或蛋白质 - 核苷酸相互作用。GTP结合蛋白也不例外。它们调节着诸如蛋白质生物合成和细胞内膜运输等多种细胞过程。最近，大量编码GTP结合蛋白以及与这些分子开关相互作用的蛋白质的基因已被克隆和表达。其中一些的三维结构也已得到阐明。
