鸟嘌呤核苷酸交换因子、GTP酶激活蛋白、鸟嘌呤核苷酸解离抑制因子及效应蛋白：更近距离（三维）观察Ras相关GTP结合蛋白的调控

GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins.

作者信息

Geyer M, Wittinghofer A

机构信息

Max-Planck-Institut für medizinische Forschung, Abteilung Biophysik, Heidelberg, Germany.

出版信息

Curr Opin Struct Biol. 1997 Dec;7(6):786-92. doi: 10.1016/s0959-440x(97)80147-9.

DOI:10.1016/s0959-440x(97)80147-9

PMID:9434896

Abstract

Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated.

摘要

细胞生物学依赖于大分子之间的相互作用，如蛋白质 - DNA、蛋白质 - 蛋白质或蛋白质 - 核苷酸相互作用。GTP结合蛋白也不例外。它们调节着诸如蛋白质生物合成和细胞内膜运输等多种细胞过程。最近，大量编码GTP结合蛋白以及与这些分子开关相互作用的蛋白质的基因已被克隆和表达。其中一些的三维结构也已得到阐明。