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蜡样芽孢杆菌及其食物中毒毒素。

Bacillus cereus and its food poisoning toxins.

作者信息

Granum P E, Lund T

机构信息

Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway.

出版信息

FEMS Microbiol Lett. 1997 Dec 15;157(2):223-8. doi: 10.1111/j.1574-6968.1997.tb12776.x.

Abstract

Bacillus cereus is becoming one of the more important causes of food poisoning in the industrialised world. It produces one emetic toxin and three different enterotoxins. The emetic toxin is a ring-shaped structure of three repeats of four amino and/or oxy acids: [D-O-Leu-D-Ala-L-O-Val-L-Val]3. This ring structure has a molecular mass of 1.2 kDa, and is chemically closely related to the potassium ionophore valinomycin. Two of the three enterotoxins have been shown to be involved in food poisoning. They both consist of three different proteins that act together. One of these enterotoxins is also a haemolysin. This haemolytic enterotoxin is transcribed from one operon. The third enterotoxin is a single component protein, but has not been shown to be involved in food poisoning.

摘要

蜡样芽孢杆菌正成为工业化国家食物中毒的一个越来越重要的原因。它产生一种呕吐毒素和三种不同的肠毒素。呕吐毒素是一种由四个氨基酸和/或羟基酸的三个重复序列组成的环状结构:[D-O-亮氨酸-D-丙氨酸-L-O-缬氨酸-L-缬氨酸]3。这种环状结构的分子量为1.2 kDa,在化学上与钾离子载体缬氨霉素密切相关。三种肠毒素中的两种已被证明与食物中毒有关。它们都由三种共同起作用的不同蛋白质组成。其中一种肠毒素也是一种溶血素。这种溶血性肠毒素由一个操纵子转录。第三种肠毒素是一种单组分蛋白质,但尚未被证明与食物中毒有关。

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