一种从蜡样芽孢杆菌中分离出的新型十二肽缩酚酸肽——蜡样芽胞杆菌溶血素，可导致人喉表皮样癌细胞（HEp-2细胞）形成液泡。
A novel dodecadepsipeptide, cereulide, isolated from Bacillus cereus causes vacuole formation in HEp-2 cells.
作者信息
Agata N, Mori M, Ohta M, Suwan S, Ohtani I, Isobe M
机构信息
Nagoya City Public Health Research Institute, Japan.
出版信息
FEMS Microbiol Lett. 1994 Aug 1;121(1):31-4. doi: 10.1111/j.1574-6968.1994.tb07071.x.
A HEp-2 cell-vacuolation factor was extracted and purified from the culture supernatant of a Bacillus cereus strain which caused emetic-syndrome food poisoning. The final preparation was chemically pure, and the toxin was named as cereulide. Mass spectrometry, NMR studies and chemical degradation revealed that the cereulide is a cyclic dodecadepsipeptide, (D-O-Leu-D-Ala-L-O-Val-L-Val)3, which is closely related to the potassium ionophore, valinomycin.
从一株引起呕吐综合征食物中毒的蜡样芽孢杆菌菌株的培养上清液中提取并纯化出一种人喉表皮样癌细胞空泡化因子。最终制品化学纯，该毒素被命名为蜡样芽胞杆菌环肽。质谱分析、核磁共振研究及化学降解表明，蜡样芽胞杆菌环肽是一种环十二肽缩酚酸肽，(D-O-亮氨酸-D-丙氨酸-L-O-缬氨酸-L-缬氨酸)3，与钾离子载体缬氨霉素密切相关。
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