δ9-四氢大麻酚对组织培养的Lewis肺癌细胞的影响。

Effects of delta9-tetrahydrocannabinol in Lewis lung adenocarcinoma cells in tissue culture.

作者信息

White A C, Munson J A, Munson A E, Carchman R A

出版信息

J Natl Cancer Inst. 1976 Mar;56(3):655-8. doi: 10.1093/jnci/56.3.655.

DOI:10.1093/jnci/56.3.655

Abstract

We found a dose-related decrease in DNA synthesis in transformed cell cultures treated with delta9-tetrahydrocannabinol (delta9-THC). The decrease, observed over a 4-hour period, was not accompanied by a change in the radioactive precursor pool as compared to that of control culture. The distribution of labeled products clearly differed from that observed after treatment with cytosine arabinoside. delta9-THC inhibited DNA synthesis at some point beyond the uptake of 3H-thymidine.

摘要

我们发现，在用δ9-四氢大麻酚（δ9-THC）处理的转化细胞培养物中，DNA合成呈剂量相关下降。在4小时期间观察到的这种下降，与对照培养物相比，放射性前体池没有变化。标记产物的分布与用阿糖胞苷处理后观察到的明显不同。δ9-THC在3H-胸腺嘧啶摄取后的某个点抑制了DNA合成。