注射到蛙卵母细胞中的细胞核为研究转录调控提供了一个活细胞系统。
Injected nuclei in frog oocytes provide a living cell system for the study of transcriptional control.
作者信息
Gurdon J B, De Robertis E M, Partington G
出版信息
Nature. 1976 Mar 11;260(5547):116-20. doi: 10.1038/260116a0.
DOI:10.1038/260116a0
PMID:943701
Abstract
Human HeLa nuclei injected into Xenopus oocytes synthesise RNA continuously for up to 1 month, and some of this RNA is translated into HeLa proteins. Nuclear proteins extracted from other cells enter the injected nuclei. This living cell system can be used for the study of transcriptional controls.
摘要
将人类海拉细胞核注入非洲爪蟾卵母细胞后，其会持续合成RNA长达1个月，并且其中一些RNA会被翻译成海拉细胞的蛋白质。从其他细胞中提取的核蛋白会进入注入的细胞核。这个活细胞系统可用于研究转录调控。
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