Ferris S H, Kluger A
Silberstein Aging and Dementia Research Center, New York University Medical Center, NY 10016, USA.
Alzheimer Dis Assoc Disord. 1997;11 Suppl 6:45-9.
Because cognitive impairment is the central, defining symptom of Alzheimer disease, cognitive assessments commonly are used as primary or secondary measures of outcome in Alzheimer disease research. The authors review the cognitive functions that decline in this neurodegenerative disease and summarize the necessary features of appropriate cognitive performance tests. The characteristics, strengths, and weaknesses of the major cognitive batteries employed as outcome measures in Alzheimer disease research are reviewed. Finally, the recent contributions to the development of cognitive measures by the Alzheimer's Disease Cooperative Study are presented briefly, followed by discussion of some critical issues for future test development.
由于认知障碍是阿尔茨海默病的核心标志性症状，在阿尔茨海默病研究中，认知评估通常被用作主要或次要的结果指标。作者回顾了这种神经退行性疾病中会衰退的认知功能，并总结了适当的认知表现测试的必要特征。还回顾了在阿尔茨海默病研究中用作结果指标的主要认知测试组合的特点、优点和缺点。最后，简要介绍了阿尔茨海默病协作研究对认知测量发展的最新贡献，随后讨论了未来测试开发的一些关键问题。
