Medina V, Afonso J J, Alvarez-Arguelles H, Hernández C, González F
Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain.
JPEN J Parenter Enteral Nutr. 1998 Jan-Feb;22(1):14-7. doi: 10.1177/014860719802200114.
Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However to date in vivo animal studies have failed to show conclusive results.
We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features.
Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon.
Butyrate may inhibit the growth of tumors induced by DMH.
丁酸是膳食纤维降解的最重要副产物之一。在不同实验条件下，它是肠黏膜的重要营养因子。多项体外研究获得的数据有力地表明，丁酸盐可能是控制某些癌细胞生长的潜在治疗剂。然而，迄今为止，体内动物研究未能显示出确凿的结果。
我们在由1,2 - 二甲基肼（DMH）诱导的结肠癌发生实验模型中，评估了在盲肠（其天然产生部位）给予丁酸盐的效果。我们研究了结肠肿瘤的发生率及其主要组织学特征。
直接应用丁酸钠显著降低了结肠中肿瘤的总数以及恶性肿瘤和癌的发生率。
丁酸盐可能抑制由DMH诱导的肿瘤生长。
