Matthew I R, Frame J W
University of Birmingham, School of Dentistry, Oral Surgery Unit, United Kingdom.
J Oral Maxillofac Surg. 1998 Jan;56(1):45-50. doi: 10.1016/s0278-2391(98)90915-6.
Low-vacuum scanning electron microscopy (Ivac SEM) was used to characterize the appearance of metal particles released from stressed and unstressed Champy miniplates placed in dogs and to study the relationship of the debris to the surrounding tissues.
Under general endotracheal anesthesia, two Champy miniplates (titanium or stainless steel) were placed on the frontal bone in an animal model. One miniplate was bent to fit the curvature of the frontal bone (unstressed) and another miniplate of the same material was bent in a curve until the midpoint was raised 3 mm above the ends. The latter miniplate adapted to the skull curvature under tension during screw insertion (stressed). The miniplates and surrounding tissues were retrieved after intervals of 4, 12, and 24 weeks. Decalcified sections were prepared and examined by light microscopy and Ivac SEM.
Under Ivac SEM examination, the titanium particles had a smooth, polygonal outline. Stainless steel particles were typically spherical, with numerous small projections on the surface. Most particles were 1 to 10 microns in diameter. The tissue response to the particles was variable; some particles were covered by fibrous connective tissue or enclosed by bone, and others were intracellular.
The metal particles released from stressed or unstressed Champy miniplates were similar, and this was related to their source of origin and duration within the tissues. The tissue response to the particles appeared to depend on their location.
采用低真空扫描电子显微镜（Ivac SEM）对置于犬体内的受力和未受力的Champy微型钢板释放的金属颗粒外观进行表征，并研究碎片与周围组织的关系。
在全身气管内麻醉下，将两块Champy微型钢板（钛或不锈钢材质）置于动物模型的额骨上。一块微型钢板弯曲以适应额骨的曲率（未受力），另一块相同材料的微型钢板弯曲成曲线，直到中点比两端高出3毫米。后一块微型钢板在拧入螺钉时在张力下适应颅骨曲率（受力）。在4周、12周和24周后取出微型钢板和周围组织。制备脱钙切片并通过光学显微镜和Ivac SEM进行检查。
在Ivac SEM检查下，钛颗粒具有光滑的多边形轮廓。不锈钢颗粒通常为球形，表面有许多小突起。大多数颗粒直径为1至10微米。组织对颗粒的反应各不相同；一些颗粒被纤维结缔组织覆盖或被骨包围，另一些颗粒则位于细胞内。
受力或未受力的Champy微型钢板释放的金属颗粒相似，这与其来源和在组织内的持续时间有关。组织对颗粒的反应似乎取决于它们的位置。
