葡萄糖与蔗糖添加到基础电解质混合物中用于儿童急性肠胃炎门诊治疗的临床比较
Clinical comparison between glucose and sucrose additions to a basic electrolyte mixture in the outpatient management of acute gastroenteritis in children.
作者信息
Rahilly P M, Shepherd R, Challis D, Walker-Smith J A, Manly J
出版信息
Arch Dis Child. 1976 Feb;51(2):152-4. doi: 10.1136/adc.51.2.152.
In a double-blind trial in 94 children attending outpatients the value of glucose or a sucrose addition to a basic electrolyte mixture for the management of acute gastroenteritis was compared. Of the children treated with added sucrose 10% failed to respond compared with 27% of those treated with added glucose. This difference was significant (P=0-05), but the time to recovery in those in the two groups who responded to treatment was not significantly different. Thus, despite theoretical advantages, there was no practical advantage in using glucose rather than sucrose. A 5% sucrose electrolyte solution with its relatively low osmolality, ready availability, and ease of preparation is recommended as the treatment of choice in the outpatient management of acute gastroenteritis in infancy.
在一项针对94名门诊儿童的双盲试验中，比较了在基本电解质混合物中添加葡萄糖或蔗糖对急性胃肠炎治疗的价值。在添加蔗糖治疗的儿童中，10%无反应，而添加葡萄糖治疗的儿童中这一比例为27%。这一差异具有显著性（P = 0.05），但两组中对治疗有反应的儿童恢复时间无显著差异。因此，尽管从理论上看有优势，但使用葡萄糖而非蔗糖并无实际优势。推荐使用渗透压相对较低、随时可得且易于配制的5%蔗糖电解质溶液作为婴儿急性胃肠炎门诊治疗的首选。
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