Szabó C, Ohshima H
Children's Hospital Medical Center, Division of Critical Care, Cincinnati, Ohio 45229, USA.
Nitric Oxide. 1997 Oct;1(5):373-85. doi: 10.1006/niox.1997.0143.
Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.
一氧化氮（NO）与超氧化物迅速反应生成过氧亚硝酸根。过氧亚硝酸根是一种强效氧化剂，可与蛋白质、脂质和DNA发生反应。本文综述了同时暴露于过氧亚硝酸根或NO与超氧化物所诱导的各种DNA修饰，特别提及8-硝基鸟嘌呤和8-氧代鸟嘌呤的形成以及DNA单链断裂的诱导。此外，我们还回顾了DNA损伤过程之后可能发生的次级过程，如核酶聚（ADP-核糖）合成酶的激活、细胞凋亡和致癌作用。
