Borella P, Bargellini A, Caselgrandi E, Piccinini L
Dipartimento di Scienze Biomediche, Università degli Studi di Modena, Italy.
J Trace Elem Med Biol. 1997 Nov;11(3):162-5. doi: 10.1016/S0946-672X(97)80046-6.
Selenium, zinc and copper were measured in plasma, hair and tissue of patients affected by either breast or lung cancer and their controls. A decrease in plasma Se and Zn in women affected by breast cancer was observed, whereas plasma Cu was increased in lung cancer. No significant modification was found in hair trace element levels adjusted for the main confounders, in particular for hair treatment which altered Se content. The examined elements were highly concentrated in cancerous vs normal tissue, but results changed according to the unit used to express results. The usefulness and significance of these biomarkers of trace element status are discussed in the light of the most recent literature data.
对乳腺癌或肺癌患者及其对照的血浆、头发和组织中的硒、锌和铜进行了测量。观察到乳腺癌女性患者血浆硒和锌含量降低，而肺癌患者血浆铜含量升高。在对主要混杂因素进行调整后，头发微量元素水平未发现显著变化，尤其是头发处理会改变硒含量。与正常组织相比，所检测的元素在癌组织中高度浓缩，但结果会因表达结果所用的单位而有所不同。根据最新的文献数据，讨论了这些微量元素状态生物标志物的实用性和意义。
