Vale R D, Fletterick R J
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA.
Annu Rev Cell Dev Biol. 1997;13:745-77. doi: 10.1146/annurev.cellbio.13.1.745.
The kinesin superfamily comprises a large and structurally diverse group of microtubule-based motor proteins that produce a variety of force-generating activities within cells. This review addresses how the structures of kinesin proteins provide clues as to their biological functions and motile properties. We discuss structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities. We also discuss how the kinesin motor domain uses chemical energy from ATP hydrolysis to move along microtubules.
驱动蛋白超家族由一大类结构多样的基于微管的运动蛋白组成，这些蛋白在细胞内产生各种产生力的活动。本综述探讨了驱动蛋白的结构如何为其生物学功能和运动特性提供线索。我们讨论了所有驱动蛋白共有的结构特征，以及使相关驱动蛋白亚家族能够执行特定活动的特殊特征。我们还讨论了驱动蛋白运动结构域如何利用ATP水解产生的化学能沿着微管移动。
