Mainous A G, Hueston W J
Department of Family Practice, University of Kentucky, Lexington 40536-0284, USA.
Arch Fam Med. 1998 Jan-Feb;7(1):45-9. doi: 10.1001/archfami.7.1.45.
To examine the use and cost of the nonindicated treatment regimens of antibiotics for nonspecific upper respiratory tract infections (URIs) in a Medicaid population.
A cross-sectional sample of Kentucky Medicaid claims for 50000 people (July 1, 1993-June 30, 1994).
Episodes of care were created linking outpatient and emergency department visits for URIs to medications filled within a 5-day period.
Individuals who were seen in ambulatory care for a URI as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification codes 460 and 465. Of the 15706 episodes, 95% were outpatient office episodes. The outpatient episodes were accounted for by 8784 patients and 946 physicians.
Use of antibiotics in URI episodes. Proportionate costs and costs per episode were computed based on claims paid by Medicaid.
Sixty percent of outpatient episodes and 48% of emergency department episodes resulted in an antibiotic prescription being filled. In outpatient settings, episodes in which secondary diagnoses of either otitis media or acute sinusitis were found accounted for less than 6% of the episodes that resulted in an antibiotic prescription being filled. The most frequently filled antibiotic was amoxicillin, although second- and third-generation cephalosporins were the second most frequently occurring antibiotic class. Twenty-three percent and 9% of outpatient and emergency department episodes, respectively, resulted in a prescription filled for antihistamines. In outpatient episodes, antibiotics account for 23% of the total cost of care. In emergency department visits, antibiotics account for 8% of the cost of URIs. Antibiotics cost, on average, $9.91 for each episode of care in outpatient office visits. An estimate of the cost of antibiotics for URIs in a year for the Kentucky Medicaid program is $1.62 million.
The results indicate that a substantial proportion of resources in Medicaid are being used for nonindicated and ineffective treatments for URIs. With the increase in antibiotic-resistant pathogens and shrinking public health care funding, the current treatment for URIs should be reexamined.
研究医疗补助人群中非特异性上呼吸道感染(URIs)使用非适应症抗生素治疗方案的情况及成本。
对肯塔基州50000人(1993年7月1日至1994年6月30日)的医疗补助索赔进行横断面抽样。
通过将门诊和急诊科因URIs就诊与5天内开具的药物进行关联,生成护理事件。
根据国际疾病分类第九版临床修订版代码460和465定义,在门诊接受URIs治疗的个体。在15706例护理事件中,95%为门诊就诊事件。门诊就诊事件涉及8784名患者和946名医生。
URIs护理事件中抗生素的使用情况。根据医疗补助支付的索赔计算相应成本和每例护理事件的成本。
60%的门诊护理事件和48%的急诊科护理事件导致开具了抗生素处方。在门诊环境中,发现有中耳炎或急性鼻窦炎二级诊断的护理事件占开具抗生素处方护理事件的比例不到6%。最常开具的抗生素是阿莫西林,尽管第二代和第三代头孢菌素是第二常见的抗生素类别。分别有23%和9%的门诊和急诊科护理事件导致开具了抗组胺药处方。在门诊护理事件中,抗生素占护理总成本的23%。在急诊科就诊中,抗生素占URIs成本的8%。门诊就诊时,每例护理事件的抗生素平均成本为9.91美元。肯塔基州医疗补助计划一年中URIs抗生素的估计成本为162万美元。
结果表明,医疗补助中的大量资源被用于对URIs进行非适应症和无效治疗。随着抗生素耐药病原体的增加以及公共医疗保健资金的缩减,当前对URIs的治疗方法应重新审视。