Jørgensen N R
Osteoporosecentret, H:S Kommunehospitalet, København.
Ugeskr Laeger. 1997 Dec 29;160(1):24-8.
During the last few years, progress has been made towards the understanding of local regulation of bone remodelling especially in relation to osteoporosis. Cytokines have shown to be powerful regulators of bone resorption and formation, though under superior control from oestrogen/testosterone, parathyroidhormone and 1,25(OH)2D3. Some of the cytokines primarily enhance osteoclastic bone resorption e.g. IL-1 (Interleukin-1), TNF (Tumor Necrosis Factor) and IL-6 (Interleukin-6), while others primarily stimulate bone formation e.g. TGF-beta (Transforming Growth Factor), IGF (Insulin-like Growth Factor) and PDGF (Platelet Derived Growth Factor). Another category has complex functions with stimulation of bone formation in vitro but stimulation of bone resorption in vivo; IFN-gamma (Interferon-gamma) belongs to this category. The bone remodelling cycle is delicately regulated, and even a slight disturbance in this regulation can cause a pathological state in the bone such as osteoporosis. This paper will try to give a survey of some of the processes that regulate bone metabolism and hopefully contribute to understanding the changes in the remodelling related to osteoporosis.
在过去几年中，人们对骨重塑的局部调节，尤其是与骨质疏松症相关的调节方面取得了进展。细胞因子已被证明是骨吸收和形成的强大调节因子，尽管它们受到雌激素/睾酮、甲状旁腺激素和1,25(OH)₂D₃的高级控制。一些细胞因子主要增强破骨细胞的骨吸收，例如白细胞介素-1（IL-1）、肿瘤坏死因子（TNF）和白细胞介素-6（IL-6），而其他细胞因子主要刺激骨形成，例如转化生长因子-β（TGF-β）、胰岛素样生长因子（IGF）和血小板衍生生长因子（PDGF）。另一类具有复杂的功能，在体外刺激骨形成，但在体内刺激骨吸收；γ干扰素（IFN-γ）属于这一类。骨重塑周期受到精细调节，即使这种调节出现轻微紊乱也会导致骨骼出现病理状态，如骨质疏松症。本文将试图概述一些调节骨代谢的过程，并有望有助于理解与骨质疏松症相关的重塑变化。
