Wasada T, Aoki K, Sato A, Katsumori K, Muto K, Tomonaga O, Yokoyama H, Iwasaki N, Babazono T, Takahashi C, Iwamoto Y, Omori Y, Hizuka N
Diabetes Center, Tokyo Women's Medical College, Japan.
Endocr J. 1997 Aug;44(4):617-20. doi: 10.1507/endocrj.44.617.
With a euglycemic hyperinsulinemic clamp method, whole-body insulin resistance was assessed in 6 cases with acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. The glucose infusion rate (GIR) correlated well with the plasma IGF-I level but poorly with that of GH. Further improvement in insulin sensitivity occurred 3-4 months after operation without substantial changes in plasma levels of both GH and IGF-I or glycemic control. These results indicate that GH excess can induce insulin resistance in association with plasma IGF-I and also through undefined secondary effect.
采用正常血糖高胰岛素钳夹法，在6例伴有糖尿病的肢端肥大症患者经蝶窦腺瘤切除术前、后评估全身胰岛素抵抗情况。葡萄糖输注率（GIR）与血浆IGF-I水平相关性良好，而与GH水平相关性较差。术后3 - 4个月胰岛素敏感性进一步改善，而血浆GH、IGF-I水平及血糖控制均无显著变化。这些结果表明，GH过多可通过血浆IGF-I及未明确的继发效应诱导胰岛素抵抗。
