Ritchey M B, Palese P, Kilbourne E D
J Virol. 1976 May;18(2):738-44. doi: 10.1128/JVI.18.2.738-744.1976.
The nucleic acids of influenza A, B, and C viruses were compared. Susceptibility to nucleases demonstrates that influenza C virus, just as influenza A and B viruses, possesses single-stranded RNA as its genome. The base compositions of the RNAs of influenza A, B, and influenza C virus are almost identical and comparative analysis on polyacrylamide gels shows that the genome of influenza C/GL/1167/54 virus, like that of the RNAs of influenza A and B viruses, is segmented. Eight distinct RNA bands were found for influenza A/PR/8/34 virus and for influenza B/Lee/40 virus. The RNA of influenza C/GL/1167/54 virus separated into at least four segments. The total molecular weights of the RNA of influenza A/PR/8/34 and B/Lee/40 virus were calculated to be 5.29 X 10(6) and 6.43 X 10(6), respectively. A minimum value of 4.67 X 10(6) daltons was obtained for influenza C/GL/1167/54 virus RNA. The data suggest that influenza C viruses are true members of the influenza virus group.
对甲型、乙型和丙型流感病毒的核酸进行了比较。对核酸酶的敏感性表明，丙型流感病毒与甲型和乙型流感病毒一样，拥有单链RNA作为其基因组。甲型、乙型和丙型流感病毒RNA的碱基组成几乎相同，聚丙烯酰胺凝胶上的比较分析表明，丙型流感病毒C/GL/1167/54株的基因组与甲型和乙型流感病毒的RNA一样，是分段的。甲型流感病毒A/PR/8/34株和乙型流感病毒B/Lee/40株发现了八条不同的RNA条带。丙型流感病毒C/GL/1167/54株的RNA至少分成四个片段。甲型流感病毒A/PR/8/34株和乙型流感病毒B/Lee/40株RNA的总分子量分别计算为5.29×10⁶和6.43×10⁶。丙型流感病毒C/GL/1167/54株RNA的最小值为4.67×10⁶道尔顿。数据表明，丙型流感病毒是流感病毒群的真正成员。
