Agalar C, Usubütün S, Tütüncü E, Türkyilmaz R
Department of Infectious Diseases and Clinical Microbiology, Social Security Hospital, Kalaba-Ankara, Turkey.
Eur J Clin Microbiol Infect Dis. 1997 Nov;16(11):803-6. doi: 10.1007/BF01700409.
A clinical trial was conducted in 50 patients with blood cultures positive for Salmonella typhi or Salmonella paratyphi to compare treatment with ciprofloxacin for seven days, 500 mg b.i.d. (Group 1, 25 patients), with treatment for ten days, 750 mg b.i.d. (Group 2, 25 patients). Clinical cure was defined as defervescence of fever by day 5 of treatment, with an absence of complications and no clinical relapse. The clinical cure rate was 84% for group 1 and 96% for group 2; the difference in these rates was not statistically significant. The blood cultures of all patients were sterile by day 2 of treatment and remained so until the sixth month of follow-up. It was concluded that ciprofloxacin treatment for ten days in enteric fever is not necessary. Further studies are needed to evaluate the efficacy of shortening the duration of antibiotic therapy.
对50例血培养伤寒沙门菌或副伤寒沙门菌呈阳性的患者进行了一项临床试验，以比较两种治疗方案：一组为25例患者，给予环丙沙星治疗7天，500毫克，每日两次（第1组）；另一组为25例患者，给予环丙沙星治疗10天，750毫克，每日两次（第2组）。临床治愈定义为治疗第5天时发热消退，无并发症且无临床复发。第1组的临床治愈率为84%，第2组为96%；两组治愈率差异无统计学意义。所有患者的血培养在治疗第2天时均无菌，直至随访第六个月一直保持无菌。得出的结论是，肠热病用环丙沙星治疗10天没有必要。需要进一步研究来评估缩短抗生素治疗疗程的疗效。
